Drug interactions
Modafinil + Nalbuphine
Severity: Minor
Modafinil and Nalbuphine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Modafinil promotes wakefulness and may lessen the sedation caused by nalbuphine, but it does not reverse respiratory depression. Apparent alertness could lead to underestimation of opioid effect, and the net outcome is unpredictable.
What this interaction means in plain words
Modafinil and Nalbuphine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Modafinil belongs to Central Nervous System; Nalbuphine belongs to Musculoskeletal.
Why it happens
Opposing pharmacodynamic effects on arousal; no established pharmacokinetic interaction of significance.
What to do
Monitor respiratory rate and sedation after dose changes, and do not use alertness as the only guide to opioid dosing.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Nalbuphine
- Alvimopan + Nalbuphine Contraindicated
- Nalbuphine + Olanzapine / samidorphan Contraindicated
- Alprazolam + Nalbuphine Major
- Amobarbital + Nalbuphine Major
- Benzhydrocodone / acetaminophen + Nalbuphine Major
- Brexanolone + Nalbuphine Major
Other interactions of Modafinil
Frequently asked questions
Can I take Modafinil with Nalbuphine?
MediHelp rates the interaction as minor. Modafinil and Nalbuphine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Modafinil promotes wakefulness and may lessen the sedation caused by nalbuphine, but it does not reverse respiratory depression. Apparent alertness could lead to underestimation of opioid effect, and the net outcome is unpredictable.
How serious is the interaction between Modafinil and Nalbuphine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor respiratory rate and sedation after dose changes, and do not use alertness as the only guide to opioid dosing.
What other medicines interact with Nalbuphine?
MediHelp also lists interactions of Nalbuphine with, for example, Alvimopan, Olanzapine / samidorphan, Alprazolam. The full list is on the Nalbuphine page.
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