Drug interactions
Modafinil + Procarbazine
Severity: Moderate
Modafinil and Procarbazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Procarbazine has weak MAO-inhibiting activity, and combining it with a CNS stimulant raises the theoretical risk of a hypertensive reaction. Modafinil is not a classic sympathomimetic, so the risk is likely lower than with amphetamines but still plausible.
What this interaction means in plain words
Modafinil and Procarbazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Modafinil belongs to Central Nervous System; Procarbazine belongs to Oncology.
Why it happens
Additive pressor effects from MAO inhibition by procarbazine and the catecholaminergic stimulation of modafinil.
What to do
Monitor blood pressure and heart rate closely, and counsel patients to report severe headache or palpitations. Consider an alternative to modafinil if blood pressure rises.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Modafinil
Other interactions of Procarbazine
- Adenovirus types 4 and 7 live + Procarbazine Contraindicated
- Amitriptyline + Procarbazine Contraindicated
- Amoxapine + Procarbazine Contraindicated
- Atomoxetine + Procarbazine Contraindicated
- Bcg vaccine live + Procarbazine Contraindicated
- Brimonidine + Procarbazine Contraindicated
Frequently asked questions
Can I take Modafinil with Procarbazine?
MediHelp rates the interaction as moderate. Modafinil and Procarbazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Procarbazine has weak MAO-inhibiting activity, and combining it with a CNS stimulant raises the theoretical risk of a hypertensive reaction. Modafinil is not a classic sympathomimetic, so the risk is likely lower than with amphetamines but still plausible.
How serious is the interaction between Modafinil and Procarbazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and heart rate closely, and counsel patients to report severe headache or palpitations. Consider an alternative to modafinil if blood pressure rises.
What other medicines interact with Modafinil?
MediHelp also lists interactions of Modafinil with, for example, Lenacapavir, Leniolisib, Lorlatinib. The full list is on the Modafinil page.
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