Drug interactions
Modafinil + Sparsentan
Severity: Minor
Modafinil and Sparsentan: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sparsentan induces CYP2C19 and, as a CYP3A4 inducer, may lower modafinil exposure. This could reduce wakefulness benefit.
What this interaction means in plain words
Modafinil and Sparsentan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Modafinil belongs to Central Nervous System; Sparsentan belongs to Genitourinary.
Why it happens
Sparsentan induces CYP2C19 and CYP3A4, increasing modafinil clearance.
What to do
Monitor modafinil efficacy and increase the dose if response is lost.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Modafinil
Other interactions of Sparsentan
- Aliskiren + Sparsentan Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Sparsentan Contraindicated
- Amlodipine-olmesartan-hydrochlorothiazide + Sparsentan Contraindicated
- Amlodipine-olmesartan + Sparsentan Contraindicated
- Amlodipine-valsartan + Sparsentan Contraindicated
- Azilsartan-chlorthalidone + Sparsentan Contraindicated
Frequently asked questions
Can I take Modafinil with Sparsentan?
MediHelp rates the interaction as minor. Modafinil and Sparsentan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Sparsentan induces CYP2C19 and, as a CYP3A4 inducer, may lower modafinil exposure. This could reduce wakefulness benefit.
How serious is the interaction between Modafinil and Sparsentan?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor modafinil efficacy and increase the dose if response is lost.
What other medicines interact with Modafinil?
MediHelp also lists interactions of Modafinil with, for example, Lenacapavir, Leniolisib, Lorlatinib. The full list is on the Modafinil page.
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