Drug interactions
Modafinil + Thioridazine
Severity: Moderate
Modafinil and Thioridazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Thioridazine strongly prolongs the QT interval and is sedating, whereas modafinil is a stimulant that may increase heart rate and cause palpitations. Modafinil does not clearly alter thioridazine levels, but the stimulant effect and any arrhythmia risk in a patient already at risk of QT prolongation are of concern.
What this interaction means in plain words
Modafinil and Thioridazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Modafinil belongs to Central Nervous System; Thioridazine belongs to Central Nervous System.
Why it happens
Opposing CNS effects, with possible additive cardiovascular stimulation on top of thioridazine's QT-prolonging effect.
What to do
Obtain a baseline ECG and monitor QTc and electrolytes. Avoid the combination in patients with cardiac disease or other QT-prolonging drugs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Modafinil
Other interactions of Thioridazine
- Abiraterone + Thioridazine Contraindicated
- Adagrasib + Thioridazine Contraindicated
- Amiodarone + Thioridazine Contraindicated
- Amisulpride + Thioridazine Contraindicated
- Amitriptyline + Thioridazine Contraindicated
- Amoxapine + Thioridazine Contraindicated
Frequently asked questions
Can I take Modafinil with Thioridazine?
MediHelp rates the interaction as moderate. Modafinil and Thioridazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Thioridazine strongly prolongs the QT interval and is sedating, whereas modafinil is a stimulant that may increase heart rate and cause palpitations. Modafinil does not clearly alter thioridazine levels, but the stimulant effect and any arrhythmia risk in a patient already at risk of QT prolongation are of concern.
How serious is the interaction between Modafinil and Thioridazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and monitor QTc and electrolytes. Avoid the combination in patients with cardiac disease or other QT-prolonging drugs.
What other medicines interact with Modafinil?
MediHelp also lists interactions of Modafinil with, for example, Lenacapavir, Leniolisib, Lorlatinib. The full list is on the Modafinil page.
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