Drug interactions
Modafinil + Vonoprazan
Severity: Moderate
Modafinil and Vonoprazan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Modafinil may reduce vonoprazan exposure, possibly weakening acid suppression. Labeling advises avoiding concomitant use with strong CYP3A inducers, and moderate inducers carry a lesser concern.
What this interaction means in plain words
Modafinil and Vonoprazan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Modafinil belongs to Central Nervous System; Vonoprazan belongs to Gastrointestinal Tract.
Why it happens
Modafinil induces CYP3A4, increasing vonoprazan clearance.
What to do
Monitor for symptom recurrence and consider an alternative acid suppressant if control is lost.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Modafinil
Other interactions of Vonoprazan
- Amobarbital + Vonoprazan Major
- Apalutamide + Vonoprazan Major
- Atazanavir + Vonoprazan Major
- Carbamazepine + Vonoprazan Major
- Erlotinib + Vonoprazan Major
- Phenytoin + Vonoprazan Major
Frequently asked questions
Can I take Modafinil with Vonoprazan?
MediHelp rates the interaction as moderate. Modafinil and Vonoprazan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Modafinil may reduce vonoprazan exposure, possibly weakening acid suppression. Labeling advises avoiding concomitant use with strong CYP3A inducers, and moderate inducers carry a lesser concern.
How serious is the interaction between Modafinil and Vonoprazan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for symptom recurrence and consider an alternative acid suppressant if control is lost.
What other medicines interact with Modafinil?
MediHelp also lists interactions of Modafinil with, for example, Lenacapavir, Leniolisib, Lorlatinib. The full list is on the Modafinil page.
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