Drug interactions
Modafinil + Ziprasidone
Severity: Moderate
Modafinil and Ziprasidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ziprasidone is sedating and prolongs the QT interval, while modafinil promotes wakefulness. Modafinil may lessen sedation and could slightly lower ziprasidone exposure through CYP3A4 induction, and may cause palpitations or agitation.
What this interaction means in plain words
Modafinil and Ziprasidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Modafinil belongs to Central Nervous System; Ziprasidone belongs to Central Nervous System.
Why it happens
Opposing CNS effects, with possible weak CYP3A4 induction by modafinil and additive cardiovascular stimulation.
What to do
Monitor ECG and QTc in patients with cardiac risk factors, and monitor psychiatric response. Adjust the ziprasidone dose based on clinical effect.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Modafinil
Other interactions of Ziprasidone
- Amiodarone + Ziprasidone Contraindicated
- Amitriptyline + Ziprasidone Contraindicated
- Arsenic trioxide + Ziprasidone Contraindicated
- Bedaquiline + Ziprasidone Contraindicated
- Chloroquine + Ziprasidone Contraindicated
- Citalopram + Ziprasidone Contraindicated
Frequently asked questions
Can I take Modafinil with Ziprasidone?
MediHelp rates the interaction as moderate. Modafinil and Ziprasidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ziprasidone is sedating and prolongs the QT interval, while modafinil promotes wakefulness. Modafinil may lessen sedation and could slightly lower ziprasidone exposure through CYP3A4 induction, and may cause palpitations or agitation.
How serious is the interaction between Modafinil and Ziprasidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG and QTc in patients with cardiac risk factors, and monitor psychiatric response. Adjust the ziprasidone dose based on clinical effect.
What other medicines interact with Modafinil?
MediHelp also lists interactions of Modafinil with, for example, Lenacapavir, Leniolisib, Lorlatinib. The full list is on the Modafinil page.
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