Drug interactions
Momelotinib + Pantoprazole
Severity: Minor
Momelotinib and Pantoprazole: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Momelotinib inhibits BCRP and may increase the exposure of pantoprazole, which is a BCRP substrate. The effect is probably small given pantoprazole's safety margin.
What this interaction means in plain words
Momelotinib and Pantoprazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Momelotinib belongs to Oncology; Pantoprazole belongs to Gastrointestinal Tract.
Why it happens
Momelotinib inhibits the BCRP efflux transporter, increasing pantoprazole exposure.
What to do
No routine dose change is required. Monitor for PPI adverse effects and reduce the dose if they occur.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Pantoprazole
- Pantoprazole + Rilpivirine Contraindicated
- Acalabrutinib + Pantoprazole Major
- Atazanavir + Pantoprazole Major
- Dacomitinib + Pantoprazole Major
- Dasatinib + Pantoprazole Major
- Erlotinib + Pantoprazole Major
Other interactions of Momelotinib
- Atorvastatin + Momelotinib Moderate
- Clarithromycin + Momelotinib Moderate
- Cyclosporin + Momelotinib Moderate
- Daunorubicin + Momelotinib Moderate
- Erythromycin + Momelotinib Moderate
- Fluvastatin + Momelotinib Moderate
Frequently asked questions
Can I take Momelotinib with Pantoprazole?
MediHelp rates the interaction as minor. Momelotinib and Pantoprazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Momelotinib inhibits BCRP and may increase the exposure of pantoprazole, which is a BCRP substrate. The effect is probably small given pantoprazole's safety margin.
How serious is the interaction between Momelotinib and Pantoprazole?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine dose change is required. Monitor for PPI adverse effects and reduce the dose if they occur.
What other medicines interact with Pantoprazole?
MediHelp also lists interactions of Pantoprazole with, for example, Rilpivirine, Acalabrutinib, Atazanavir. The full list is on the Pantoprazole page.
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