Drug interactions
Momelotinib + Pazopanib
Severity: Moderate
Momelotinib and Pazopanib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pazopanib may inhibit OATP1B1/3 and raise momelotinib exposure, while momelotinib inhibits BCRP and may raise pazopanib exposure. Both effects could increase adverse reactions.
What this interaction means in plain words
Momelotinib and Pazopanib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Momelotinib belongs to Oncology; Pazopanib belongs to Oncology.
Why it happens
OATP1B1/3 inhibition by pazopanib and BCRP inhibition by momelotinib.
What to do
Monitor for toxicity of both drugs, including liver tests, and reduce pazopanib dose if adverse effects occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Pazopanib
- Adagrasib + Pazopanib Major
- Amiodarone + Pazopanib Major
- Amisulpride + Pazopanib Major
- Amobarbital + Pazopanib Major
- Anagrelide + Pazopanib Major
- Apalutamide + Pazopanib Major
Other interactions of Momelotinib
- Atorvastatin + Momelotinib Moderate
- Clarithromycin + Momelotinib Moderate
- Cyclosporin + Momelotinib Moderate
- Daunorubicin + Momelotinib Moderate
- Erythromycin + Momelotinib Moderate
- Fluvastatin + Momelotinib Moderate
Frequently asked questions
Can I take Momelotinib with Pazopanib?
MediHelp rates the interaction as moderate. Momelotinib and Pazopanib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Pazopanib may inhibit OATP1B1/3 and raise momelotinib exposure, while momelotinib inhibits BCRP and may raise pazopanib exposure. Both effects could increase adverse reactions.
How serious is the interaction between Momelotinib and Pazopanib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for toxicity of both drugs, including liver tests, and reduce pazopanib dose if adverse effects occur.
What other medicines interact with Pazopanib?
MediHelp also lists interactions of Pazopanib with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Pazopanib page.
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