Drug interactions
Momelotinib + Topotecan
Severity: Moderate
Momelotinib and Topotecan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Momelotinib inhibits BCRP and may increase topotecan exposure, which is a BCRP substrate. This could increase myelosuppression and gastrointestinal toxicity, and momelotinib itself can cause cytopenias.
What this interaction means in plain words
Momelotinib and Topotecan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Momelotinib belongs to Oncology; Topotecan belongs to Oncology.
Why it happens
BCRP inhibition by momelotinib reduces topotecan efflux and elimination.
What to do
Monitor complete blood counts frequently and consider reducing the topotecan dose if cytopenias or gastrointestinal toxicity develop.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Topotecan
- Adenovirus types 4 and 7 live + Topotecan Contraindicated
- Amiodarone + Topotecan Major
- Cisplatin + Topotecan Major
- Cobicistat + Topotecan Major
- Cyclosporin + Topotecan Major
- Darunavir + Topotecan Major
Other interactions of Momelotinib
- Atorvastatin + Momelotinib Moderate
- Clarithromycin + Momelotinib Moderate
- Cyclosporin + Momelotinib Moderate
- Daunorubicin + Momelotinib Moderate
- Erythromycin + Momelotinib Moderate
- Fluvastatin + Momelotinib Moderate
Frequently asked questions
Can I take Momelotinib with Topotecan?
MediHelp rates the interaction as moderate. Momelotinib and Topotecan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Momelotinib inhibits BCRP and may increase topotecan exposure, which is a BCRP substrate. This could increase myelosuppression and gastrointestinal toxicity, and momelotinib itself can cause cytopenias.
How serious is the interaction between Momelotinib and Topotecan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor complete blood counts frequently and consider reducing the topotecan dose if cytopenias or gastrointestinal toxicity develop.
What other medicines interact with Topotecan?
MediHelp also lists interactions of Topotecan with, for example, Adenovirus types 4 and 7 live, Amiodarone, Cisplatin. The full list is on the Topotecan page.
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