Drug interactions
Montelukast + Oxcarbazepine
Severity: Minor
Montelukast and Oxcarbazepine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oxcarbazepine is a weak-to-moderate inducer of CYP3A4 and may slightly lower montelukast concentrations. The clinical effect is expected to be small because montelukast is metabolized by several pathways.
What this interaction means in plain words
Montelukast and Oxcarbazepine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Montelukast belongs to Respiratory; Oxcarbazepine belongs to Central Nervous System.
Why it happens
Oxcarbazepine's induction of CYP3A4 may modestly increase montelukast clearance.
What to do
No routine adjustment is needed. Reassess asthma control if symptoms worsen after oxcarbazepine is started.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Montelukast
- Apalutamide + Montelukast Moderate
- Carbamazepine + Montelukast Moderate
- Deferasirox + Montelukast Moderate
- Enzalutamide + Montelukast Moderate
- Fosphenytoin + Montelukast Moderate
- Gemfibrozil + Montelukast Moderate
Other interactions of Oxcarbazepine
- Cabotegravir + Oxcarbazepine Contraindicated
- Oxcarbazepine + Rilpivirine Contraindicated
- Artemether / lumefantrine + Oxcarbazepine Major
- Atazanavir + Oxcarbazepine Major
- Benzhydrocodone / acetaminophen + Oxcarbazepine Major
- Bictegravir + Oxcarbazepine Major
Frequently asked questions
Can I take Montelukast with Oxcarbazepine?
MediHelp rates the interaction as minor. Montelukast and Oxcarbazepine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Oxcarbazepine is a weak-to-moderate inducer of CYP3A4 and may slightly lower montelukast concentrations. The clinical effect is expected to be small because montelukast is metabolized by several pathways.
How serious is the interaction between Montelukast and Oxcarbazepine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed. Reassess asthma control if symptoms worsen after oxcarbazepine is started.
What other medicines interact with Montelukast?
MediHelp also lists interactions of Montelukast with, for example, Apalutamide, Carbamazepine, Deferasirox. The full list is on the Montelukast page.
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