Drug interactions
Morphine + Tepotinib
Severity: Moderate
Morphine and Tepotinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tepotinib inhibits P-glycoprotein and may increase exposure to P-gp substrates such as morphine. The increase would raise the risk of opioid adverse effects like sedation and respiratory depression, although clinical data for morphine are limited.
What this interaction means in plain words
Morphine and Tepotinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Morphine belongs to Musculoskeletal; Tepotinib belongs to Oncology.
Why it happens
Inhibition of intestinal and blood-brain barrier P-glycoprotein efflux, raising morphine exposure.
What to do
Monitor for increased sedation and respiratory depression and reduce the morphine dose if needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Morphine
- Alvimopan + Morphine Contraindicated
- Isocarboxazid + Morphine Contraindicated
- Morphine + Olanzapine / samidorphan Contraindicated
- Morphine + Phenelzine Contraindicated
- Morphine + Tranylcypromine Contraindicated
- Alfentanil + Morphine Major
Other interactions of Tepotinib
- Colchicine + Tepotinib Major
- Digoxin + Tepotinib Major
- Tepotinib + Vincristine Major
- Amiodarone + Tepotinib Moderate
- Apixaban + Tepotinib Moderate
- Atorvastatin + Tepotinib Moderate
Frequently asked questions
Can I take Morphine with Tepotinib?
MediHelp rates the interaction as moderate. Morphine and Tepotinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tepotinib inhibits P-glycoprotein and may increase exposure to P-gp substrates such as morphine. The increase would raise the risk of opioid adverse effects like sedation and respiratory depression, although clinical data for morphine are limited.
How serious is the interaction between Morphine and Tepotinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for increased sedation and respiratory depression and reduce the morphine dose if needed.
What other medicines interact with Morphine?
MediHelp also lists interactions of Morphine with, for example, Alvimopan, Isocarboxazid, Olanzapine / samidorphan. The full list is on the Morphine page.
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