Drug interactions
Moxifloxacin + Osilodrostat
Severity: Moderate
Moxifloxacin and Osilodrostat: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Osilodrostat is labelled with a risk of QT prolongation, and moxifloxacin also lengthens the QT interval. Taken together they may increase the risk of torsades de pointes, particularly with hypokalemia.
What this interaction means in plain words
Moxifloxacin and Osilodrostat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Moxifloxacin belongs to Anti Bacterial; Osilodrostat belongs to Endocrine.
Why it happens
Additive pharmacodynamic QT prolongation.
What to do
Obtain an ECG before and during co-treatment and correct potassium and magnesium. Use an alternative antibiotic if QTc is markedly prolonged.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Moxifloxacin
- Amiodarone + Moxifloxacin Contraindicated
- Arsenic trioxide + Moxifloxacin Contraindicated
- Disopyramide + Moxifloxacin Contraindicated
- Dofetilide + Moxifloxacin Contraindicated
- Dronedarone + Moxifloxacin Contraindicated
- Droperidol + Moxifloxacin Contraindicated
Other interactions of Osilodrostat
Frequently asked questions
Can I take Moxifloxacin with Osilodrostat?
MediHelp rates the interaction as moderate. Moxifloxacin and Osilodrostat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Osilodrostat is labelled with a risk of QT prolongation, and moxifloxacin also lengthens the QT interval. Taken together they may increase the risk of torsades de pointes, particularly with hypokalemia.
How serious is the interaction between Moxifloxacin and Osilodrostat?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain an ECG before and during co-treatment and correct potassium and magnesium. Use an alternative antibiotic if QTc is markedly prolonged.
What other medicines interact with Moxifloxacin?
MediHelp also lists interactions of Moxifloxacin with, for example, Amiodarone, Arsenic trioxide, Disopyramide. The full list is on the Moxifloxacin page.
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