Drug interactions
Moxifloxacin + Osimertinib
Severity: Moderate
Moxifloxacin and Osimertinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Osimertinib can prolong the QTc interval and moxifloxacin has a well-known QT effect. Together they may increase the risk of serious ventricular arrhythmia.
What this interaction means in plain words
Moxifloxacin and Osimertinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Moxifloxacin belongs to Anti Bacterial; Osimertinib belongs to Oncology.
Why it happens
Additive pharmacodynamic prolongation of cardiac repolarisation.
What to do
Monitor ECG and electrolytes periodically and correct abnormalities. Choose a non-QT-prolonging antibiotic where possible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Moxifloxacin
- Amiodarone + Moxifloxacin Contraindicated
- Arsenic trioxide + Moxifloxacin Contraindicated
- Disopyramide + Moxifloxacin Contraindicated
- Dofetilide + Moxifloxacin Contraindicated
- Dronedarone + Moxifloxacin Contraindicated
- Droperidol + Moxifloxacin Contraindicated
Other interactions of Osimertinib
Frequently asked questions
Can I take Moxifloxacin with Osimertinib?
MediHelp rates the interaction as moderate. Moxifloxacin and Osimertinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Osimertinib can prolong the QTc interval and moxifloxacin has a well-known QT effect. Together they may increase the risk of serious ventricular arrhythmia.
How serious is the interaction between Moxifloxacin and Osimertinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG and electrolytes periodically and correct abnormalities. Choose a non-QT-prolonging antibiotic where possible.
What other medicines interact with Moxifloxacin?
MediHelp also lists interactions of Moxifloxacin with, for example, Amiodarone, Arsenic trioxide, Disopyramide. The full list is on the Moxifloxacin page.
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