Drug interactions
Moxifloxacin + Rilpivirine
Severity: Moderate
Moxifloxacin and Rilpivirine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rilpivirine prolongs the QT interval at supratherapeutic doses, and moxifloxacin is a recognised QT-prolonging antibiotic. Co-administration may add to the risk of torsades de pointes, particularly with other risk factors.
What this interaction means in plain words
Moxifloxacin and Rilpivirine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Moxifloxacin belongs to Anti Bacterial; Rilpivirine belongs to Anti Virals.
Why it happens
Additive pharmacodynamic QT prolongation.
What to do
Consider a baseline ECG and monitor it during combined therapy, correcting electrolyte abnormalities. Choose an alternative antibiotic if the patient has other QT risk factors.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Moxifloxacin
- Amiodarone + Moxifloxacin Contraindicated
- Arsenic trioxide + Moxifloxacin Contraindicated
- Disopyramide + Moxifloxacin Contraindicated
- Dofetilide + Moxifloxacin Contraindicated
- Dronedarone + Moxifloxacin Contraindicated
- Droperidol + Moxifloxacin Contraindicated
Other interactions of Rilpivirine
- Carbamazepine + Rilpivirine Contraindicated
- Dexamethasone + Rilpivirine Contraindicated
- Dexlansoprazole + Rilpivirine Contraindicated
- Efavirenz + Rilpivirine Contraindicated
- Eslicarbazepine + Rilpivirine Contraindicated
- Esomeprazole + Rilpivirine Contraindicated
Frequently asked questions
Can I take Moxifloxacin with Rilpivirine?
MediHelp rates the interaction as moderate. Moxifloxacin and Rilpivirine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Rilpivirine prolongs the QT interval at supratherapeutic doses, and moxifloxacin is a recognised QT-prolonging antibiotic. Co-administration may add to the risk of torsades de pointes, particularly with other risk factors.
How serious is the interaction between Moxifloxacin and Rilpivirine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider a baseline ECG and monitor it during combined therapy, correcting electrolyte abnormalities. Choose an alternative antibiotic if the patient has other QT risk factors.
What other medicines interact with Moxifloxacin?
MediHelp also lists interactions of Moxifloxacin with, for example, Amiodarone, Arsenic trioxide, Disopyramide. The full list is on the Moxifloxacin page.
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