Drug interactions
Moxisylyte + Silodosin
Severity: Moderate
Moxisylyte and Silodosin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Moxisylyte is an alpha-adrenergic blocker, so combining it with silodosin adds alpha-1 blockade. This may cause marked orthostatic hypotension, dizziness and syncope.
What this interaction means in plain words
Moxisylyte and Silodosin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive alpha-adrenoceptor antagonism causing vasodilation.
What to do
Avoid duplicating alpha-blockade where possible. If both are needed, monitor orthostatic blood pressure and use the lowest effective doses.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Silodosin
- Atazanavir + Silodosin Contraindicated
- Conivaptan + Silodosin Contraindicated
- Darunavir + Silodosin Contraindicated
- Fosamprenavir + Silodosin Contraindicated
- Indinavir + Silodosin Contraindicated
- Itraconazole + Silodosin Contraindicated
Frequently asked questions
Can I take Moxisylyte with Silodosin?
MediHelp rates the interaction as moderate. Moxisylyte and Silodosin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Moxisylyte is an alpha-adrenergic blocker, so combining it with silodosin adds alpha-1 blockade. This may cause marked orthostatic hypotension, dizziness and syncope.
How serious is the interaction between Moxisylyte and Silodosin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid duplicating alpha-blockade where possible. If both are needed, monitor orthostatic blood pressure and use the lowest effective doses.
What other medicines interact with Silodosin?
MediHelp also lists interactions of Silodosin with, for example, Atazanavir, Conivaptan, Darunavir. The full list is on the Silodosin page.
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