Drug interactions
Mycophenolate mofetil + Rilonacept
Severity: Major
Mycophenolate mofetil and Rilonacept: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rilonacept blocks interleukin-1 and can raise the risk of serious infection. Combined with mycophenolate, which suppresses lymphocyte proliferation, the overall immunosuppression and infection risk may be additive.
What this interaction means in plain words
Mycophenolate mofetil and Rilonacept can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Mycophenolate mofetil belongs to Miscellaneous; Rilonacept belongs to Miscellaneous.
Why it happens
Additive pharmacodynamic immunosuppression through IL-1 blockade and inhibition of purine synthesis in lymphocytes.
What to do
Avoid the combination where possible; if both are required, monitor closely for signs of infection and stop rilonacept if a serious infection develops.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Mycophenolate mofetil
- Adenovirus types 4 and 7 live + Mycophenolate mofetil Contraindicated
- Bcg vaccine live + Mycophenolate mofetil Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Mycophenolate mofetil Contraindicated
- Measles mumps and rubella vaccine live + Mycophenolate mofetil Contraindicated
- Measles mumps rubella and varicella vaccine live + Mycophenolate mofetil Contraindicated
- Measles vaccine + Mycophenolate mofetil Contraindicated
Other interactions of Rilonacept
Frequently asked questions
Can I take Mycophenolate mofetil with Rilonacept?
MediHelp rates the interaction as major. Mycophenolate mofetil and Rilonacept can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Rilonacept blocks interleukin-1 and can raise the risk of serious infection. Combined with mycophenolate, which suppresses lymphocyte proliferation, the overall immunosuppression and infection risk may be additive.
How serious is the interaction between Mycophenolate mofetil and Rilonacept?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible; if both are required, monitor closely for signs of infection and stop rilonacept if a serious infection develops.
What other medicines interact with Mycophenolate mofetil?
MediHelp also lists interactions of Mycophenolate mofetil with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Mycophenolate mofetil page.
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