Drug interactions
Mycophenolate mofetil + Sirolimus
Severity: Moderate
Mycophenolate mofetil and Sirolimus: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
This combination is used in transplant regimens, but together the drugs add to immunosuppression and the risk of infection and cytopenias. Sirolimus may also cause hyperlipidemia and impaired wound healing.
What this interaction means in plain words
Mycophenolate mofetil and Sirolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Mycophenolate mofetil belongs to Miscellaneous; Sirolimus belongs to Miscellaneous.
Why it happens
Additive immunosuppression through inhibition of lymphocyte proliferation by different pathways (IMPDH inhibition and mTOR inhibition).
What to do
Use under transplant specialist supervision with planned dosing; monitor sirolimus trough levels, blood counts and signs of infection.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Mycophenolate mofetil and Sirolimus, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Mycophenolate mofetil
- Adenovirus types 4 and 7 live + Mycophenolate mofetil Contraindicated
- Bcg vaccine live + Mycophenolate mofetil Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Mycophenolate mofetil Contraindicated
- Measles mumps and rubella vaccine live + Mycophenolate mofetil Contraindicated
- Measles mumps rubella and varicella vaccine live + Mycophenolate mofetil Contraindicated
- Measles vaccine + Mycophenolate mofetil Contraindicated
Other interactions of Sirolimus
- Adenovirus types 4 and 7 live + Sirolimus Contraindicated
- Bcg vaccine live + Sirolimus Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Sirolimus Contraindicated
- Ketoconazole + Sirolimus Contraindicated
- Levoketoconazole + Sirolimus Contraindicated
- Measles mumps and rubella vaccine live + Sirolimus Contraindicated
Frequently asked questions
Can I take Mycophenolate mofetil with Sirolimus?
MediHelp rates the interaction as moderate. Mycophenolate mofetil and Sirolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. This combination is used in transplant regimens, but together the drugs add to immunosuppression and the risk of infection and cytopenias. Sirolimus may also cause hyperlipidemia and impaired wound healing.
How serious is the interaction between Mycophenolate mofetil and Sirolimus?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use under transplant specialist supervision with planned dosing; monitor sirolimus trough levels, blood counts and signs of infection.
What other medicines interact with Mycophenolate mofetil?
MediHelp also lists interactions of Mycophenolate mofetil with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Mycophenolate mofetil page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
