Drug interactions
Mycophenolate mofetil + Tacrolimus
Severity: Moderate
Mycophenolate mofetil and Tacrolimus: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
This is a standard transplant combination, but it produces additive immunosuppression and raises the risk of infection and malignancy. Tacrolimus may also raise mycophenolic acid exposure modestly by reducing its enterohepatic recirculation effects, with variable results.
What this interaction means in plain words
Mycophenolate mofetil and Tacrolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Mycophenolate mofetil belongs to Miscellaneous; Tacrolimus belongs to Miscellaneous.
Why it happens
Additive pharmacodynamic immunosuppression via calcineurin inhibition and IMPDH inhibition.
What to do
Use within a planned transplant regimen, monitor tacrolimus trough levels, renal function and blood counts, and screen for infection.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Mycophenolate mofetil
- Adenovirus types 4 and 7 live + Mycophenolate mofetil Contraindicated
- Bcg vaccine live + Mycophenolate mofetil Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Mycophenolate mofetil Contraindicated
- Measles mumps and rubella vaccine live + Mycophenolate mofetil Contraindicated
- Measles mumps rubella and varicella vaccine live + Mycophenolate mofetil Contraindicated
- Measles vaccine + Mycophenolate mofetil Contraindicated
Other interactions of Tacrolimus
- Adenovirus types 4 and 7 live + Tacrolimus Contraindicated
- Bcg vaccine live + Tacrolimus Contraindicated
- Cidofovir + Tacrolimus Contraindicated
- Cyclosporin + Tacrolimus Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Tacrolimus Contraindicated
- Measles mumps and rubella vaccine live + Tacrolimus Contraindicated
Frequently asked questions
Can I take Mycophenolate mofetil with Tacrolimus?
MediHelp rates the interaction as moderate. Mycophenolate mofetil and Tacrolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. This is a standard transplant combination, but it produces additive immunosuppression and raises the risk of infection and malignancy. Tacrolimus may also raise mycophenolic acid exposure modestly by reducing its enterohepatic recirculation effects, with variable results.
How serious is the interaction between Mycophenolate mofetil and Tacrolimus?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use within a planned transplant regimen, monitor tacrolimus trough levels, renal function and blood counts, and screen for infection.
What other medicines interact with Mycophenolate mofetil?
MediHelp also lists interactions of Mycophenolate mofetil with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Mycophenolate mofetil page.
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