Drug interactions
Mycophenolate mofetil + Trastuzumab deruxtecan
Severity: Moderate
Mycophenolate mofetil and Trastuzumab deruxtecan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Trastuzumab deruxtecan causes neutropenia, and mycophenolate also suppresses bone marrow and immune function. Combined use may increase cytopenias and infection risk.
What this interaction means in plain words
Mycophenolate mofetil and Trastuzumab deruxtecan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Mycophenolate mofetil belongs to Miscellaneous; Trastuzumab deruxtecan belongs to Oncology.
Why it happens
Additive myelosuppression and immunosuppression from the topoisomerase I inhibitor payload and mycophenolate.
What to do
Monitor complete blood counts before each cycle and during therapy. Hold or reduce doses for significant neutropenia and treat infections promptly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Mycophenolate mofetil and Trastuzumab deruxtecan, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Mycophenolate mofetil
- Adenovirus types 4 and 7 live + Mycophenolate mofetil Contraindicated
- Bcg vaccine live + Mycophenolate mofetil Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Mycophenolate mofetil Contraindicated
- Measles mumps and rubella vaccine live + Mycophenolate mofetil Contraindicated
- Measles mumps rubella and varicella vaccine live + Mycophenolate mofetil Contraindicated
- Measles vaccine + Mycophenolate mofetil Contraindicated
Other interactions of Trastuzumab deruxtecan
Frequently asked questions
Can I take Mycophenolate mofetil with Trastuzumab deruxtecan?
MediHelp rates the interaction as moderate. Mycophenolate mofetil and Trastuzumab deruxtecan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Trastuzumab deruxtecan causes neutropenia, and mycophenolate also suppresses bone marrow and immune function. Combined use may increase cytopenias and infection risk.
How serious is the interaction between Mycophenolate mofetil and Trastuzumab deruxtecan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor complete blood counts before each cycle and during therapy. Hold or reduce doses for significant neutropenia and treat infections promptly.
What other medicines interact with Mycophenolate mofetil?
MediHelp also lists interactions of Mycophenolate mofetil with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Mycophenolate mofetil page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
