Drug interactions
Nabilone + Perphenazine
Severity: Moderate
Nabilone and Perphenazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Perphenazine is a sedating antipsychotic, and nabilone adds further CNS depression, which can increase drowsiness and impair coordination. Both agents may also cause orthostatic hypotension and tachycardia.
What this interaction means in plain words
Nabilone and Perphenazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Nabilone belongs to Gastrointestinal Tract; Perphenazine belongs to Central Nervous System.
Why it happens
Additive CNS depressant and hypotensive effects.
What to do
Monitor sedation and orthostatic blood pressure, and counsel against driving until tolerance is established. Reduce the dose of either drug if oversedation occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nabilone
Other interactions of Perphenazine
- Ibutilide + Perphenazine Contraindicated
- Perphenazine + Pimozide Contraindicated
- Perphenazine + Thioridazine Contraindicated
- Adagrasib + Perphenazine Major
- Alfentanil + Perphenazine Major
- Amiodarone + Perphenazine Major
Frequently asked questions
Can I take Nabilone with Perphenazine?
MediHelp rates the interaction as moderate. Nabilone and Perphenazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Perphenazine is a sedating antipsychotic, and nabilone adds further CNS depression, which can increase drowsiness and impair coordination. Both agents may also cause orthostatic hypotension and tachycardia.
How serious is the interaction between Nabilone and Perphenazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation and orthostatic blood pressure, and counsel against driving until tolerance is established. Reduce the dose of either drug if oversedation occurs.
What other medicines interact with Nabilone?
MediHelp also lists interactions of Nabilone with, for example, Alfentanil, Amobarbital, Belladonna and opium. The full list is on the Nabilone page.
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