Drug interactions
Nabilone + Temazepam
Severity: Moderate
Nabilone and Temazepam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs depress the central nervous system, so taking them together can deepen drowsiness, slow psychomotor performance and impair coordination. Falls, confusion and impaired driving are the main concerns, especially in older adults.
What this interaction means in plain words
Nabilone and Temazepam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Nabilone belongs to Gastrointestinal Tract; Temazepam belongs to Central Nervous System.
Why it happens
Additive CNS depression from cannabinoid receptor agonism combined with benzodiazepine GABA-A potentiation.
What to do
Start with the lowest effective doses and counsel patients to avoid driving and alcohol. Monitor for excessive sedation and reduce either dose if it occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nabilone
Other interactions of Temazepam
- Alprazolam + Temazepam Major
- Amobarbital + Temazepam Major
- Buprenorphine + Temazepam Major
- Butorphanol + Temazepam Major
- Carisoprodol + Temazepam Major
- Chloral hydrate + Temazepam Major
Frequently asked questions
Can I take Nabilone with Temazepam?
MediHelp rates the interaction as moderate. Nabilone and Temazepam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs depress the central nervous system, so taking them together can deepen drowsiness, slow psychomotor performance and impair coordination. Falls, confusion and impaired driving are the main concerns, especially in older adults.
How serious is the interaction between Nabilone and Temazepam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Start with the lowest effective doses and counsel patients to avoid driving and alcohol. Monitor for excessive sedation and reduce either dose if it occurs.
What other medicines interact with Nabilone?
MediHelp also lists interactions of Nabilone with, for example, Alfentanil, Amobarbital, Belladonna and opium. The full list is on the Nabilone page.
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