Drug interactions
Nadolol + Sevoflurane
Severity: Moderate
Nadolol and Sevoflurane: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Beta-blockade blunts the compensatory heart rate and contractility response to the vasodilation and myocardial depression caused by sevoflurane. This can lead to pronounced hypotension and bradycardia during anesthesia.
What this interaction means in plain words
Nadolol and Sevoflurane can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Nadolol belongs to Cardiovascular; Sevoflurane belongs to Central Nervous System.
Why it happens
Additive negative inotropic and hypotensive effects: beta-adrenergic blockade combined with volatile anesthetic vasodilation and myocardial depression.
What to do
Generally continue beta-blockers perioperatively but monitor blood pressure and ECG closely. Have vasopressors and anticholinergics available and adjust anesthetic depth to hemodynamic response.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sevoflurane
Other interactions of Nadolol
- Acebutolol + Nadolol Major
- Adrenaline-articaine + Nadolol Major
- Albuterol + Nadolol Major
- Amifostine + Nadolol Major
- Amiodarone + Nadolol Major
- Arformoterol + Nadolol Major
Frequently asked questions
Can I take Nadolol with Sevoflurane?
MediHelp rates the interaction as moderate. Nadolol and Sevoflurane can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Beta-blockade blunts the compensatory heart rate and contractility response to the vasodilation and myocardial depression caused by sevoflurane. This can lead to pronounced hypotension and bradycardia during anesthesia.
How serious is the interaction between Nadolol and Sevoflurane?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Generally continue beta-blockers perioperatively but monitor blood pressure and ECG closely. Have vasopressors and anticholinergics available and adjust anesthetic depth to hemodynamic response.
What other medicines interact with Sevoflurane?
MediHelp also lists interactions of Sevoflurane with, for example, Amiodarone, Amisulpride, Arsenic trioxide. The full list is on the Sevoflurane page.
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