Drug interactions
Nadolol + Stiripentol
Severity: Minor
Nadolol and Stiripentol: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Stiripentol inhibits P-glycoprotein and may increase nadolol exposure, since nadolol is a P-gp substrate. This could intensify bradycardia and hypotension.
What this interaction means in plain words
Nadolol and Stiripentol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Nadolol belongs to Cardiovascular; Stiripentol belongs to Central Nervous System.
Why it happens
Inhibition of P-glycoprotein mediated efflux by stiripentol, raising nadolol concentrations.
What to do
Monitor heart rate and blood pressure after starting stiripentol. Reduce the nadolol dose if bradycardia or hypotension develops.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Nadolol
- Acebutolol + Nadolol Major
- Adrenaline-articaine + Nadolol Major
- Albuterol + Nadolol Major
- Amifostine + Nadolol Major
- Amiodarone + Nadolol Major
- Arformoterol + Nadolol Major
Other interactions of Stiripentol
Frequently asked questions
Can I take Nadolol with Stiripentol?
MediHelp rates the interaction as minor. Nadolol and Stiripentol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Stiripentol inhibits P-glycoprotein and may increase nadolol exposure, since nadolol is a P-gp substrate. This could intensify bradycardia and hypotension.
How serious is the interaction between Nadolol and Stiripentol?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate and blood pressure after starting stiripentol. Reduce the nadolol dose if bradycardia or hypotension develops.
What other medicines interact with Nadolol?
MediHelp also lists interactions of Nadolol with, for example, Acebutolol, Adrenaline-articaine, Albuterol. The full list is on the Nadolol page.
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