Drug interactions
Nadolol + Tiotropium-olodaterol
Severity: Major
Nadolol and Tiotropium-olodaterol: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nadolol is a non-selective beta-blocker that antagonizes the bronchodilator effect of olodaterol and may trigger severe bronchospasm in patients with COPD or asthma. Therapeutic efficacy of both drugs may be reduced.
What this interaction means in plain words
Nadolol and Tiotropium-olodaterol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Nadolol belongs to Cardiovascular; Tiotropium-olodaterol belongs to Respiratory.
Why it happens
Competitive beta2-receptor antagonism by a non-selective beta-blocker.
What to do
Avoid nadolol in patients with obstructive airway disease who need olodaterol and use a cardioselective beta-blocker or another drug class if possible. If unavoidable, monitor respiratory symptoms and lung function closely.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Tiotropium-olodaterol
Other interactions of Nadolol
- Acebutolol + Nadolol Major
- Adrenaline-articaine + Nadolol Major
- Albuterol + Nadolol Major
- Amifostine + Nadolol Major
- Amiodarone + Nadolol Major
- Arformoterol + Nadolol Major
Frequently asked questions
Can I take Nadolol with Tiotropium-olodaterol?
MediHelp rates the interaction as major. Nadolol and Tiotropium-olodaterol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Nadolol is a non-selective beta-blocker that antagonizes the bronchodilator effect of olodaterol and may trigger severe bronchospasm in patients with COPD or asthma. Therapeutic efficacy of both drugs may be reduced.
How serious is the interaction between Nadolol and Tiotropium-olodaterol?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid nadolol in patients with obstructive airway disease who need olodaterol and use a cardioselective beta-blocker or another drug class if possible. If unavoidable, monitor respiratory symptoms and lung function closely.
What other medicines interact with Tiotropium-olodaterol?
MediHelp also lists interactions of Tiotropium-olodaterol with, for example, Amisulpride, Arformoterol, Arsenic trioxide. The full list is on the Tiotropium-olodaterol page.
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