Drug interactions
Nafcillin + Rolapitant
Severity: Moderate
Nafcillin and Rolapitant: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nafcillin can induce CYP3A4 and may lower rolapitant exposure. Reduced rolapitant levels could weaken its protection against delayed chemotherapy-induced nausea and vomiting.
What this interaction means in plain words
Nafcillin and Rolapitant can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Nafcillin induces hepatic and intestinal CYP3A4, increasing rolapitant clearance (a weak to moderate inducer effect, less potent than rifampin).
What to do
Monitor for breakthrough nausea and vomiting during co-therapy, and add or optimise other antiemetics if control is inadequate. Consider an alternative antibiotic if prolonged therapy is needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Rolapitant
- Pimozide + Rolapitant Contraindicated
- Rolapitant + Thioridazine Contraindicated
- Atomoxetine + Rolapitant Major
- Deutetrabenazine + Rolapitant Major
- Eliglustat + Rolapitant Major
- Flecainide + Rolapitant Major
Frequently asked questions
Can I take Nafcillin with Rolapitant?
MediHelp rates the interaction as moderate. Nafcillin and Rolapitant can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nafcillin can induce CYP3A4 and may lower rolapitant exposure. Reduced rolapitant levels could weaken its protection against delayed chemotherapy-induced nausea and vomiting.
How serious is the interaction between Nafcillin and Rolapitant?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for breakthrough nausea and vomiting during co-therapy, and add or optimise other antiemetics if control is inadequate. Consider an alternative antibiotic if prolonged therapy is needed.
What other medicines interact with Rolapitant?
MediHelp also lists interactions of Rolapitant with, for example, Pimozide, Thioridazine, Atomoxetine. The full list is on the Rolapitant page.
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