Drug interactions
Nalbuphine + Sevoflurane
Severity: Major
Nalbuphine and Sevoflurane: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Opioids reduce the amount of volatile anaesthetic required and add to its respiratory and cardiovascular depression. Hypotension, slow breathing and prolonged recovery sedation can occur.
What this interaction means in plain words
Nalbuphine and Sevoflurane can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Nalbuphine belongs to Musculoskeletal; Sevoflurane belongs to Central Nervous System.
Why it happens
Additive central nervous system, respiratory and cardiovascular depression.
What to do
Use only under anaesthetic supervision, adjusting sevoflurane concentration to effect. Monitor ventilation, oxygenation and blood pressure throughout and into recovery.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Nalbuphine
- Alvimopan + Nalbuphine Contraindicated
- Nalbuphine + Olanzapine / samidorphan Contraindicated
- Alprazolam + Nalbuphine Major
- Amobarbital + Nalbuphine Major
- Benzhydrocodone / acetaminophen + Nalbuphine Major
- Brexanolone + Nalbuphine Major
Other interactions of Sevoflurane
Frequently asked questions
Can I take Nalbuphine with Sevoflurane?
MediHelp rates the interaction as major. Nalbuphine and Sevoflurane can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Opioids reduce the amount of volatile anaesthetic required and add to its respiratory and cardiovascular depression. Hypotension, slow breathing and prolonged recovery sedation can occur.
How serious is the interaction between Nalbuphine and Sevoflurane?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use only under anaesthetic supervision, adjusting sevoflurane concentration to effect. Monitor ventilation, oxygenation and blood pressure throughout and into recovery.
What other medicines interact with Nalbuphine?
MediHelp also lists interactions of Nalbuphine with, for example, Alvimopan, Olanzapine / samidorphan, Alprazolam. The full list is on the Nalbuphine page.
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