Drug interactions
Nalbuphine + Trazodone
Severity: Moderate
Nalbuphine and Trazodone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs cause sedation, and together they may increase drowsiness, dizziness and orthostatic hypotension. Impaired psychomotor performance raises the risk of falls and accidents.
What this interaction means in plain words
Nalbuphine and Trazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Nalbuphine belongs to Musculoskeletal; Trazodone belongs to Central Nervous System.
Why it happens
Additive central nervous system depression and alpha-1 blockade-related hypotension.
What to do
Use low starting doses and counsel about driving and alcohol. Reduce the dose if excess sedation or hypotension occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nalbuphine
- Alvimopan + Nalbuphine Contraindicated
- Nalbuphine + Olanzapine / samidorphan Contraindicated
- Alprazolam + Nalbuphine Major
- Amobarbital + Nalbuphine Major
- Benzhydrocodone / acetaminophen + Nalbuphine Major
- Brexanolone + Nalbuphine Major
Other interactions of Trazodone
- Arsenic trioxide + Trazodone Contraindicated
- Ibutilide + Trazodone Contraindicated
- Isocarboxazid + Trazodone Contraindicated
- Levoketoconazole + Trazodone Contraindicated
- Methylene blue + Trazodone Contraindicated
- Phenelzine + Trazodone Contraindicated
Frequently asked questions
Can I take Nalbuphine with Trazodone?
MediHelp rates the interaction as moderate. Nalbuphine and Trazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs cause sedation, and together they may increase drowsiness, dizziness and orthostatic hypotension. Impaired psychomotor performance raises the risk of falls and accidents.
How serious is the interaction between Nalbuphine and Trazodone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use low starting doses and counsel about driving and alcohol. Reduce the dose if excess sedation or hypotension occurs.
What other medicines interact with Nalbuphine?
MediHelp also lists interactions of Nalbuphine with, for example, Alvimopan, Olanzapine / samidorphan, Alprazolam. The full list is on the Nalbuphine page.
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