Drug interactions
Nalbuphine + Trimipramine
Severity: Moderate
Nalbuphine and Trimipramine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Trimipramine is a very sedating tricyclic antidepressant, and together with nalbuphine it can cause marked drowsiness and impaired alertness. Anticholinergic effects and orthostatic hypotension may also be more troublesome.
What this interaction means in plain words
Nalbuphine and Trimipramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Nalbuphine belongs to Musculoskeletal; Trimipramine belongs to Central Nervous System.
Why it happens
Additive central nervous system depression from opioid activity and the antihistaminic, anticholinergic and alpha-blocking effects of the tricyclic.
What to do
Begin with low doses and monitor for oversedation, hypotension and anticholinergic effects. Advise the patient not to drive until the response is known.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nalbuphine
- Alvimopan + Nalbuphine Contraindicated
- Nalbuphine + Olanzapine / samidorphan Contraindicated
- Alprazolam + Nalbuphine Major
- Amobarbital + Nalbuphine Major
- Benzhydrocodone / acetaminophen + Nalbuphine Major
- Brexanolone + Nalbuphine Major
Other interactions of Trimipramine
- Disopyramide + Trimipramine Contraindicated
- Dofetilide + Trimipramine Contraindicated
- Ibutilide + Trimipramine Contraindicated
- Isocarboxazid + Trimipramine Contraindicated
- Pentamidine + Trimipramine Contraindicated
- Phenelzine + Trimipramine Contraindicated
Frequently asked questions
Can I take Nalbuphine with Trimipramine?
MediHelp rates the interaction as moderate. Nalbuphine and Trimipramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Trimipramine is a very sedating tricyclic antidepressant, and together with nalbuphine it can cause marked drowsiness and impaired alertness. Anticholinergic effects and orthostatic hypotension may also be more troublesome.
How serious is the interaction between Nalbuphine and Trimipramine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Begin with low doses and monitor for oversedation, hypotension and anticholinergic effects. Advise the patient not to drive until the response is known.
What other medicines interact with Nalbuphine?
MediHelp also lists interactions of Nalbuphine with, for example, Alvimopan, Olanzapine / samidorphan, Alprazolam. The full list is on the Nalbuphine page.
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