Drug interactions
Naldemedine + Nevirapine
Severity: Moderate
Naldemedine and Nevirapine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nevirapine may reduce naldemedine concentrations and so blunt its effect on opioid-induced constipation. Strong CYP3A inducers significantly lower naldemedine exposure.
What this interaction means in plain words
Naldemedine and Nevirapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Naldemedine belongs to Gastrointestinal Tract; Nevirapine belongs to Anti Virals.
Why it happens
CYP3A4 induction by nevirapine increases naldemedine metabolism.
What to do
Avoid coadministration where possible. If used, monitor for loss of laxative effect and consider an alternative.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nevirapine
- Elbasvir / grazoprevir + Nevirapine Contraindicated
- Nevirapine + Ranolazine Contraindicated
- Nevirapine + St john's wort Contraindicated
- Abemaciclib + Nevirapine Major
- Acalabrutinib + Nevirapine Major
- Amobarbital + Nevirapine Major
Other interactions of Naldemedine
- Bupropion-naltrexone + Naldemedine Major
- Naldemedine + Naltrexone Major
- Naldemedine + Phenytoin Major
- Naldemedine + Rifampicin Major
- Amobarbital + Naldemedine Moderate
- Apalutamide + Naldemedine Moderate
Frequently asked questions
Can I take Naldemedine with Nevirapine?
MediHelp rates the interaction as moderate. Naldemedine and Nevirapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nevirapine may reduce naldemedine concentrations and so blunt its effect on opioid-induced constipation. Strong CYP3A inducers significantly lower naldemedine exposure.
How serious is the interaction between Naldemedine and Nevirapine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid coadministration where possible. If used, monitor for loss of laxative effect and consider an alternative.
What other medicines interact with Nevirapine?
MediHelp also lists interactions of Nevirapine with, for example, Elbasvir / grazoprevir, Ranolazine, St john's wort. The full list is on the Nevirapine page.
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