Drug interactions
Naloxegol + Zileuton
Severity: Moderate
Naloxegol and Zileuton: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Naloxegol is a CYP3A4 substrate, and zileuton may modestly raise its levels. Increased exposure can cause opioid withdrawal-like symptoms, abdominal pain and diarrhea.
What this interaction means in plain words
Naloxegol and Zileuton can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Naloxegol belongs to Gastrointestinal Tract; Zileuton belongs to Respiratory.
Why it happens
Zileuton inhibition of CYP3A4 metabolism of naloxegol.
What to do
Monitor for abdominal pain, diarrhea and opioid withdrawal symptoms. Reduce naloxegol to 12.5 mg daily if adverse effects occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Zileuton
- Fezolinetant + Zileuton Contraindicated
- Pimozide + Zileuton Contraindicated
- Alosetron + Zileuton Major
- Clozapine + Zileuton Major
- Lomitapide + Zileuton Major
- Lonafarnib + Zileuton Major
Other interactions of Naloxegol
- Clarithromycin + Naloxegol Contraindicated
- Itraconazole + Naloxegol Contraindicated
- Ketoconazole + Naloxegol Contraindicated
- Naloxegol + Posaconazole Contraindicated
- Naloxegol + Voriconazole Contraindicated
- Bupropion-naltrexone + Naloxegol Major
Frequently asked questions
Can I take Naloxegol with Zileuton?
MediHelp rates the interaction as moderate. Naloxegol and Zileuton can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Naloxegol is a CYP3A4 substrate, and zileuton may modestly raise its levels. Increased exposure can cause opioid withdrawal-like symptoms, abdominal pain and diarrhea.
How serious is the interaction between Naloxegol and Zileuton?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for abdominal pain, diarrhea and opioid withdrawal symptoms. Reduce naloxegol to 12.5 mg daily if adverse effects occur.
What other medicines interact with Zileuton?
MediHelp also lists interactions of Zileuton with, for example, Fezolinetant, Pimozide, Alosetron. The full list is on the Zileuton page.
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