Drug interactions
Naratriptan + Ondansetron
Severity: Minor
Naratriptan and Ondansetron: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs have serotonergic activity, and serotonin syndrome has been reported rarely with this kind of combination. In practice the pairing is often used for migraine with nausea and the risk appears low.
What this interaction means in plain words
Naratriptan and Ondansetron have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Naratriptan belongs to Central Nervous System; Ondansetron belongs to Gastrointestinal Tract.
Why it happens
Theoretical additive serotonergic effects.
What to do
No routine change is needed; advise patients to report agitation, tremor, sweating or diarrhea. Stop both drugs if serotonin syndrome is suspected.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ondansetron
- Apomorphine + Ondansetron Contraindicated
- Ondansetron + Thioridazine Contraindicated
- Ondansetron + Vandetanib Contraindicated
- Adagrasib + Ondansetron Major
- Amiodarone + Ondansetron Major
- Amisulpride + Ondansetron Major
Other interactions of Naratriptan
- Almotriptan + Naratriptan Contraindicated
- Dihydroergotamine intranasal + Naratriptan Contraindicated
- Dihydroergotamine + Naratriptan Contraindicated
- Eletriptan + Naratriptan Contraindicated
- Ergoloid mesylates + Naratriptan Contraindicated
- Ergotamine + Naratriptan Contraindicated
Frequently asked questions
Can I take Naratriptan with Ondansetron?
MediHelp rates the interaction as minor. Naratriptan and Ondansetron have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Both drugs have serotonergic activity, and serotonin syndrome has been reported rarely with this kind of combination. In practice the pairing is often used for migraine with nausea and the risk appears low.
How serious is the interaction between Naratriptan and Ondansetron?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine change is needed; advise patients to report agitation, tremor, sweating or diarrhea. Stop both drugs if serotonin syndrome is suspected.
What other medicines interact with Ondansetron?
MediHelp also lists interactions of Ondansetron with, for example, Apomorphine, Thioridazine, Vandetanib. The full list is on the Ondansetron page.
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