Drug interactions
Naratriptan + Ozanimod
Severity: Moderate
Naratriptan and Ozanimod: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ozanimod's active metabolite inhibits MAO-B in vitro, and the labeling warns of hypertensive reactions with drugs affecting norepinephrine or serotonin. Naratriptan adds vasoconstrictive and serotonergic effects. The interaction is mostly theoretical.
What this interaction means in plain words
Naratriptan and Ozanimod can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Naratriptan belongs to Central Nervous System; Ozanimod belongs to Central Nervous System.
Why it happens
Possible MAO-B inhibition by an ozanimod metabolite adds to the monoaminergic and pressor effects of the triptan.
What to do
Monitor blood pressure during concurrent use and advise the patient to report severe headache or palpitations. Consider alternatives if hypertension develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Naratriptan
- Almotriptan + Naratriptan Contraindicated
- Dihydroergotamine intranasal + Naratriptan Contraindicated
- Dihydroergotamine + Naratriptan Contraindicated
- Eletriptan + Naratriptan Contraindicated
- Ergoloid mesylates + Naratriptan Contraindicated
- Ergotamine + Naratriptan Contraindicated
Other interactions of Ozanimod
- Isocarboxazid + Ozanimod Contraindicated
- Linezolid + Ozanimod Contraindicated
- Ozanimod + Phenelzine Contraindicated
- Ozanimod + Procarbazine Contraindicated
- Ozanimod + Rasagiline Contraindicated
- Ozanimod + Safinamide Contraindicated
Frequently asked questions
Can I take Naratriptan with Ozanimod?
MediHelp rates the interaction as moderate. Naratriptan and Ozanimod can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ozanimod's active metabolite inhibits MAO-B in vitro, and the labeling warns of hypertensive reactions with drugs affecting norepinephrine or serotonin. Naratriptan adds vasoconstrictive and serotonergic effects. The interaction is mostly theoretical.
How serious is the interaction between Naratriptan and Ozanimod?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure during concurrent use and advise the patient to report severe headache or palpitations. Consider alternatives if hypertension develops.
What other medicines interact with Naratriptan?
MediHelp also lists interactions of Naratriptan with, for example, Almotriptan, Dihydroergotamine intranasal, Dihydroergotamine. The full list is on the Naratriptan page.
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