Drug interactions
Naratriptan + Risperidone
Severity: Moderate
Naratriptan and Risperidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs have serotonergic activity, and concurrent use has been associated in theory with serotonin syndrome. The risk appears low in practice. Risperidone's dopamine blockade can also contribute to neuroleptic malignant syndrome in susceptible patients.
What this interaction means in plain words
Naratriptan and Risperidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Naratriptan belongs to Central Nervous System; Risperidone belongs to Central Nervous System.
Why it happens
Possible additive serotonergic effects (5-HT1B/1D agonism with 5-HT2A antagonism); the mechanism is not firmly established.
What to do
Counsel patients to report agitation, fever, tremor, rigidity or diarrhea promptly. Monitor for serotonin toxicity or neuroleptic malignant syndrome after starting.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Naratriptan and Risperidone, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Risperidone
- Ibutilide + Risperidone Contraindicated
- Risperidone + Vandetanib Contraindicated
- Adagrasib + Risperidone Major
- Amiodarone + Risperidone Major
- Amisulpride + Risperidone Major
- Amoxapine + Risperidone Major
Other interactions of Naratriptan
- Almotriptan + Naratriptan Contraindicated
- Dihydroergotamine intranasal + Naratriptan Contraindicated
- Dihydroergotamine + Naratriptan Contraindicated
- Eletriptan + Naratriptan Contraindicated
- Ergoloid mesylates + Naratriptan Contraindicated
- Ergotamine + Naratriptan Contraindicated
Frequently asked questions
Can I take Naratriptan with Risperidone?
MediHelp rates the interaction as moderate. Naratriptan and Risperidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs have serotonergic activity, and concurrent use has been associated in theory with serotonin syndrome. The risk appears low in practice. Risperidone's dopamine blockade can also contribute to neuroleptic malignant syndrome in susceptible patients.
How serious is the interaction between Naratriptan and Risperidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel patients to report agitation, fever, tremor, rigidity or diarrhea promptly. Monitor for serotonin toxicity or neuroleptic malignant syndrome after starting.
What other medicines interact with Risperidone?
MediHelp also lists interactions of Risperidone with, for example, Ibutilide, Vandetanib, Adagrasib. The full list is on the Risperidone page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
