Drug interactions
Naratriptan + Rizatriptan
Severity: Major
Naratriptan and Rizatriptan: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Taking two triptans close together produces additive vasoconstrictive effects, including on the coronary arteries. This raises the risk of cardiovascular ischemic events and blood pressure elevation without proven additional benefit.
What this interaction means in plain words
Naratriptan and Rizatriptan can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Naratriptan belongs to Central Nervous System; Rizatriptan belongs to Central Nervous System.
Why it happens
Additive 5-HT1B/1D receptor-mediated vasoconstriction.
What to do
Separate doses of different triptans by at least 24 hours. Use a non-triptan rescue medication if the first triptan is ineffective.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Rizatriptan
- Almotriptan + Rizatriptan Contraindicated
- Dihydroergotamine intranasal + Rizatriptan Contraindicated
- Dihydroergotamine + Rizatriptan Contraindicated
- Eletriptan + Rizatriptan Contraindicated
- Ergoloid mesylates + Rizatriptan Contraindicated
- Ergotamine + Rizatriptan Contraindicated
Other interactions of Naratriptan
- Almotriptan + Naratriptan Contraindicated
- Dihydroergotamine intranasal + Naratriptan Contraindicated
- Dihydroergotamine + Naratriptan Contraindicated
- Eletriptan + Naratriptan Contraindicated
- Ergoloid mesylates + Naratriptan Contraindicated
- Ergotamine + Naratriptan Contraindicated
Frequently asked questions
Can I take Naratriptan with Rizatriptan?
MediHelp rates the interaction as major. Naratriptan and Rizatriptan can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Taking two triptans close together produces additive vasoconstrictive effects, including on the coronary arteries. This raises the risk of cardiovascular ischemic events and blood pressure elevation without proven additional benefit.
How serious is the interaction between Naratriptan and Rizatriptan?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Separate doses of different triptans by at least 24 hours. Use a non-triptan rescue medication if the first triptan is ineffective.
What other medicines interact with Rizatriptan?
MediHelp also lists interactions of Rizatriptan with, for example, Almotriptan, Dihydroergotamine intranasal, Dihydroergotamine. The full list is on the Rizatriptan page.
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