Drug interactions
Naratriptan + Tedizolid
Severity: Moderate
Naratriptan and Tedizolid: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Naratriptan is a 5-HT1B/1D agonist, and tedizolid is a weak reversible MAO inhibitor. Together they could theoretically increase the risk of serotonin syndrome. Naratriptan is not mainly metabolized by MAO-A, so the risk is probably low.
What this interaction means in plain words
Naratriptan and Tedizolid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Naratriptan belongs to Central Nervous System; Tedizolid belongs to Anti Bacterial.
Why it happens
Additive serotonergic effects from a 5-HT1B/1D agonist and weak MAO inhibition by tedizolid.
What to do
Monitor for signs of serotonin toxicity during co-use. Consider a non-serotonergic antibiotic if the patient has frequent triptan use.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tedizolid
- Bupropion + Tedizolid Major
- Cyproheptadine + Tedizolid Major
- Deferiprone + Tedizolid Major
- Isocarboxazid + Tedizolid Major
- Meperidine + Tedizolid Major
- Methamphetamine + Tedizolid Major
Other interactions of Naratriptan
- Almotriptan + Naratriptan Contraindicated
- Dihydroergotamine intranasal + Naratriptan Contraindicated
- Dihydroergotamine + Naratriptan Contraindicated
- Eletriptan + Naratriptan Contraindicated
- Ergoloid mesylates + Naratriptan Contraindicated
- Ergotamine + Naratriptan Contraindicated
Frequently asked questions
Can I take Naratriptan with Tedizolid?
MediHelp rates the interaction as moderate. Naratriptan and Tedizolid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Naratriptan is a 5-HT1B/1D agonist, and tedizolid is a weak reversible MAO inhibitor. Together they could theoretically increase the risk of serotonin syndrome. Naratriptan is not mainly metabolized by MAO-A, so the risk is probably low.
How serious is the interaction between Naratriptan and Tedizolid?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for signs of serotonin toxicity during co-use. Consider a non-serotonergic antibiotic if the patient has frequent triptan use.
What other medicines interact with Tedizolid?
MediHelp also lists interactions of Tedizolid with, for example, Bupropion, Cyproheptadine, Deferiprone. The full list is on the Tedizolid page.
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