Drug interactions
Naratriptan + Tramadol
Severity: Moderate
Naratriptan and Tramadol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs enhance serotonergic activity, so using them together may raise the risk of serotonin syndrome, with agitation, tremor, hyperthermia and autonomic instability. Reported cases with triptans are uncommon, but tramadol also lowers the seizure threshold.
What this interaction means in plain words
Naratriptan and Tramadol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Naratriptan belongs to Central Nervous System; Tramadol belongs to Musculoskeletal.
Why it happens
Additive serotonergic effects from tramadol reuptake inhibition and triptan 5-HT1B/1D agonism.
What to do
Counsel the patient to report agitation, tremor, sweating or fever promptly, and watch for these signs after starting or increasing either drug. Stop one of the drugs if serotonin syndrome is suspected.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tramadol
- Isocarboxazid + Tramadol Contraindicated
- Olanzapine / samidorphan + Tramadol Contraindicated
- Phenelzine + Tramadol Contraindicated
- Procarbazine + Tramadol Contraindicated
- Rasagiline + Tramadol Contraindicated
- Safinamide + Tramadol Contraindicated
Other interactions of Naratriptan
- Almotriptan + Naratriptan Contraindicated
- Dihydroergotamine intranasal + Naratriptan Contraindicated
- Dihydroergotamine + Naratriptan Contraindicated
- Eletriptan + Naratriptan Contraindicated
- Ergoloid mesylates + Naratriptan Contraindicated
- Ergotamine + Naratriptan Contraindicated
Frequently asked questions
Can I take Naratriptan with Tramadol?
MediHelp rates the interaction as moderate. Naratriptan and Tramadol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs enhance serotonergic activity, so using them together may raise the risk of serotonin syndrome, with agitation, tremor, hyperthermia and autonomic instability. Reported cases with triptans are uncommon, but tramadol also lowers the seizure threshold.
How serious is the interaction between Naratriptan and Tramadol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel the patient to report agitation, tremor, sweating or fever promptly, and watch for these signs after starting or increasing either drug. Stop one of the drugs if serotonin syndrome is suspected.
What other medicines interact with Tramadol?
MediHelp also lists interactions of Tramadol with, for example, Isocarboxazid, Olanzapine / samidorphan, Phenelzine. The full list is on the Tramadol page.
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