Drug interactions
Nateglinide + Ticlopidine
Severity: Moderate
Nateglinide and Ticlopidine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ticlopidine may inhibit CYP2C9 and raise nateglinide exposure, potentially causing hypoglycemia. The effect is expected to be modest.
What this interaction means in plain words
Nateglinide and Ticlopidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Nateglinide belongs to Endocrine; Ticlopidine belongs to Cardiovascular.
Why it happens
Inhibition of CYP2C9-mediated nateglinide metabolism by ticlopidine.
What to do
Monitor blood glucose when ticlopidine is started or stopped and counsel on hypoglycemia symptoms. Reduce nateglinide dose if hypoglycemia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ticlopidine
Other interactions of Nateglinide
- Albiglutide + Nateglinide Moderate
- Alogliptin-metformin + Nateglinide Moderate
- Alogliptin-pioglitazone + Nateglinide Moderate
- Alogliptin + Nateglinide Moderate
- Alpelisib + Nateglinide Moderate
- Amiodarone + Nateglinide Moderate
Frequently asked questions
Can I take Nateglinide with Ticlopidine?
MediHelp rates the interaction as moderate. Nateglinide and Ticlopidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ticlopidine may inhibit CYP2C9 and raise nateglinide exposure, potentially causing hypoglycemia. The effect is expected to be modest.
How serious is the interaction between Nateglinide and Ticlopidine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when ticlopidine is started or stopped and counsel on hypoglycemia symptoms. Reduce nateglinide dose if hypoglycemia occurs.
What other medicines interact with Ticlopidine?
MediHelp also lists interactions of Ticlopidine with, for example, Mavacamten, Abrocitinib, Acetylsalicylic acid. The full list is on the Ticlopidine page.
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