Drug interactions
Nebivolol + Ranolazine
Severity: Minor
Nebivolol and Ranolazine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ranolazine weakly inhibits CYP2D6 and may modestly increase nebivolol levels. The clinical effect is usually small, though additive lowering of heart rate and blood pressure is possible.
What this interaction means in plain words
Nebivolol and Ranolazine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Nebivolol belongs to Cardiovascular; Ranolazine belongs to Cardiovascular.
Why it happens
Ranolazine weakly inhibits CYP2D6-mediated metabolism of nebivolol.
What to do
Monitor heart rate and blood pressure when starting ranolazine. Adjust nebivolol only if symptomatic bradycardia or hypotension occurs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Nebivolol
- Acebutolol + Nebivolol Major
- Aldesleukin + Nebivolol Major
- Amiodarone + Nebivolol Major
- Atenolol-chlorthalidone + Nebivolol Major
- Atenolol + Nebivolol Major
- Betaxolol + Nebivolol Major
Other interactions of Ranolazine
- Adagrasib + Ranolazine Contraindicated
- Amobarbital + Ranolazine Contraindicated
- Apalutamide + Ranolazine Contraindicated
- Butabarbital + Ranolazine Contraindicated
- Carbamazepine + Ranolazine Contraindicated
- Clarithromycin + Ranolazine Contraindicated
Frequently asked questions
Can I take Nebivolol with Ranolazine?
MediHelp rates the interaction as minor. Nebivolol and Ranolazine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Ranolazine weakly inhibits CYP2D6 and may modestly increase nebivolol levels. The clinical effect is usually small, though additive lowering of heart rate and blood pressure is possible.
How serious is the interaction between Nebivolol and Ranolazine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate and blood pressure when starting ranolazine. Adjust nebivolol only if symptomatic bradycardia or hypotension occurs.
What other medicines interact with Nebivolol?
MediHelp also lists interactions of Nebivolol with, for example, Acebutolol, Aldesleukin, Amiodarone. The full list is on the Nebivolol page.
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