Drug interactions
Nebivolol + Sevoflurane
Severity: Moderate
Nebivolol and Sevoflurane: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Volatile anesthetics such as sevoflurane depress myocardial contractility and cause vasodilation, and beta-blockade blunts the compensatory heart rate response. Together they can produce more pronounced hypotension and bradycardia during anesthesia.
What this interaction means in plain words
Nebivolol and Sevoflurane can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Nebivolol belongs to Cardiovascular; Sevoflurane belongs to Central Nervous System.
Why it happens
Additive pharmacodynamic cardiovascular depression from anesthetic-induced vasodilation and negative inotropy combined with beta-1 blockade.
What to do
Generally continue the beta-blocker perioperatively and tell the anesthesia team. Monitor blood pressure and heart rate closely and have vasopressors or anticholinergics available.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nebivolol
- Acebutolol + Nebivolol Major
- Aldesleukin + Nebivolol Major
- Amiodarone + Nebivolol Major
- Atenolol-chlorthalidone + Nebivolol Major
- Atenolol + Nebivolol Major
- Betaxolol + Nebivolol Major
Other interactions of Sevoflurane
Frequently asked questions
Can I take Nebivolol with Sevoflurane?
MediHelp rates the interaction as moderate. Nebivolol and Sevoflurane can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Volatile anesthetics such as sevoflurane depress myocardial contractility and cause vasodilation, and beta-blockade blunts the compensatory heart rate response. Together they can produce more pronounced hypotension and bradycardia during anesthesia.
How serious is the interaction between Nebivolol and Sevoflurane?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Generally continue the beta-blocker perioperatively and tell the anesthesia team. Monitor blood pressure and heart rate closely and have vasopressors or anticholinergics available.
What other medicines interact with Nebivolol?
MediHelp also lists interactions of Nebivolol with, for example, Acebutolol, Aldesleukin, Amiodarone. The full list is on the Nebivolol page.
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