Drug interactions
Nebivolol + Sotalol
Severity: Major
Nebivolol and Sotalol: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sotalol is itself a non-selective beta-blocker with class III antiarrhythmic activity, so adding nebivolol duplicates beta-blockade. This increases the risk of severe bradycardia, AV block, and hypotension, and QT prolongation from sotalol continues to matter.
What this interaction means in plain words
Nebivolol and Sotalol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Nebivolol belongs to Cardiovascular; Sotalol belongs to Cardiovascular.
Why it happens
Additive beta-adrenergic blockade on the sinus node, AV node, and vasculature.
What to do
Avoid combining them and use only one beta-blocking agent. If both are unavoidable, monitor ECG, heart rate, and blood pressure closely.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Nebivolol
- Acebutolol + Nebivolol Major
- Aldesleukin + Nebivolol Major
- Amiodarone + Nebivolol Major
- Atenolol-chlorthalidone + Nebivolol Major
- Atenolol + Nebivolol Major
- Betaxolol + Nebivolol Major
Other interactions of Sotalol
- Arsenic trioxide + Sotalol Contraindicated
- Artemether / lumefantrine + Sotalol Contraindicated
- Disopyramide + Sotalol Contraindicated
- Dofetilide + Sotalol Contraindicated
- Dronedarone + Sotalol Contraindicated
- Droperidol + Sotalol Contraindicated
Frequently asked questions
Can I take Nebivolol with Sotalol?
MediHelp rates the interaction as major. Nebivolol and Sotalol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Sotalol is itself a non-selective beta-blocker with class III antiarrhythmic activity, so adding nebivolol duplicates beta-blockade. This increases the risk of severe bradycardia, AV block, and hypotension, and QT prolongation from sotalol continues to matter.
How serious is the interaction between Nebivolol and Sotalol?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining them and use only one beta-blocking agent. If both are unavoidable, monitor ECG, heart rate, and blood pressure closely.
What other medicines interact with Nebivolol?
MediHelp also lists interactions of Nebivolol with, for example, Acebutolol, Aldesleukin, Amiodarone. The full list is on the Nebivolol page.
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