Drug interactions
Nefazodone + Silodosin
Severity: Contraindicated
Nefazodone and Silodosin: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nefazodone is a strong CYP3A4 inhibitor and can substantially increase silodosin exposure. This raises the risk of orthostatic hypotension and syncope.
What this interaction means in plain words
Nefazodone and Silodosin are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Why it happens
Nefazodone strongly inhibits CYP3A4, markedly reducing silodosin metabolism.
What to do
Avoid the combination as strong CYP3A4 inhibitors are contraindicated with silodosin. Choose a different antidepressant or alpha-blocker.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Silodosin
- Atazanavir + Silodosin Contraindicated
- Conivaptan + Silodosin Contraindicated
- Darunavir + Silodosin Contraindicated
- Fosamprenavir + Silodosin Contraindicated
- Indinavir + Silodosin Contraindicated
- Itraconazole + Silodosin Contraindicated
Frequently asked questions
Can I take Nefazodone with Silodosin?
MediHelp rates the interaction as contraindicated. Nefazodone and Silodosin are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Nefazodone is a strong CYP3A4 inhibitor and can substantially increase silodosin exposure. This raises the risk of orthostatic hypotension and syncope.
How serious is the interaction between Nefazodone and Silodosin?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination as strong CYP3A4 inhibitors are contraindicated with silodosin. Choose a different antidepressant or alpha-blocker.
What other medicines interact with Silodosin?
MediHelp also lists interactions of Silodosin with, for example, Atazanavir, Conivaptan, Darunavir. The full list is on the Silodosin page.
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