Drug interactions
Neomycin + Paromomycin
Severity: Moderate
Neomycin and Paromomycin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both are aminoglycosides given orally for gut-related indications. Although absorption is normally low, it can rise with inflamed or ulcerated bowel or renal impairment, and the combination adds to the risk of kidney and inner ear injury. It also offers no therapeutic benefit over using one agent.
What this interaction means in plain words
Neomycin and Paromomycin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Neomycin belongs to Anti Bacterial; Paromomycin belongs to Anti Bacterial.
Why it happens
Additive aminoglycoside nephrotoxicity and ototoxicity once systemic absorption occurs.
What to do
Avoid using both together; choose a single agent. If unavoidable, monitor serum creatinine and hearing, especially with renal impairment or bowel damage.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Neomycin
- Amikacin + Neomycin Major
- Amphotericin b deoxycholate + Neomycin Major
- Capreomycin + Neomycin Major
- Cidofovir + Neomycin Major
- Colistin + Neomycin Major
- Ethacrynic acid + Neomycin Major
Other interactions of Paromomycin
- Cidofovir + Paromomycin Major
- Adefovir + Paromomycin Moderate
- Amikacin + Paromomycin Moderate
- Amphotericin b + Paromomycin Moderate
- Atracurium + Paromomycin Moderate
- Bacitracin-neomycin-polymyxin + Paromomycin Moderate
Frequently asked questions
Can I take Neomycin with Paromomycin?
MediHelp rates the interaction as moderate. Neomycin and Paromomycin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both are aminoglycosides given orally for gut-related indications. Although absorption is normally low, it can rise with inflamed or ulcerated bowel or renal impairment, and the combination adds to the risk of kidney and inner ear injury. It also offers no therapeutic benefit over using one agent.
How serious is the interaction between Neomycin and Paromomycin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid using both together; choose a single agent. If unavoidable, monitor serum creatinine and hearing, especially with renal impairment or bowel damage.
What other medicines interact with Neomycin?
MediHelp also lists interactions of Neomycin with, for example, Amikacin, Amphotericin b deoxycholate, Capreomycin. The full list is on the Neomycin page.
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