Drug interactions
Netupitant-palonosetron + Pacritinib
Severity: Major
Netupitant-palonosetron and Pacritinib: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pacritinib is metabolized by CYP3A4, and netupitant may raise its exposure. Higher levels may increase the risk of QT prolongation, bleeding and diarrhea.
What this interaction means in plain words
Netupitant-palonosetron and Pacritinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Netupitant-palonosetron belongs to Gastrointestinal Tract; Pacritinib belongs to Oncology.
Why it happens
Netupitant inhibits CYP3A4 metabolism of pacritinib.
What to do
Avoid if possible and choose another antiemetic regimen. If unavoidable, monitor ECG, electrolytes and for bleeding, and adjust the pacritinib dose per labeling.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Netupitant-palonosetron and Pacritinib, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Netupitant-palonosetron
- Apomorphine + Netupitant-palonosetron Contraindicated
- Flibanserin + Netupitant-palonosetron Contraindicated
- Apalutamide + Netupitant-palonosetron Major
- Avapritinib + Netupitant-palonosetron Major
- Carbamazepine + Netupitant-palonosetron Major
- Cobimetinib + Netupitant-palonosetron Major
Other interactions of Pacritinib
- Clarithromycin + Pacritinib Contraindicated
- Ketoconazole + Pacritinib Contraindicated
- Pacritinib + Posaconazole Contraindicated
- Pacritinib + Voriconazole Contraindicated
- Amiodarone + Pacritinib Major
- Carbamazepine + Pacritinib Major
Frequently asked questions
Can I take Netupitant-palonosetron with Pacritinib?
MediHelp rates the interaction as major. Netupitant-palonosetron and Pacritinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Pacritinib is metabolized by CYP3A4, and netupitant may raise its exposure. Higher levels may increase the risk of QT prolongation, bleeding and diarrhea.
How serious is the interaction between Netupitant-palonosetron and Pacritinib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if possible and choose another antiemetic regimen. If unavoidable, monitor ECG, electrolytes and for bleeding, and adjust the pacritinib dose per labeling.
What other medicines interact with Netupitant-palonosetron?
MediHelp also lists interactions of Netupitant-palonosetron with, for example, Apomorphine, Flibanserin, Apalutamide. The full list is on the Netupitant-palonosetron page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
