Drug interactions
Netupitant-palonosetron + Posaconazole
Severity: Moderate
Netupitant-palonosetron and Posaconazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Posaconazole is a strong CYP3A4 inhibitor and can raise netupitant concentrations. The labeling for netupitant does not require dose adjustment with strong inhibitors, but higher exposure may increase adverse effects such as headache, constipation and fatigue.
What this interaction means in plain words
Netupitant-palonosetron and Posaconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Netupitant-palonosetron belongs to Gastrointestinal Tract; Posaconazole belongs to Anti Fungals.
Why it happens
Posaconazole strongly inhibits CYP3A4, reducing netupitant metabolism.
What to do
No empirical dose adjustment is needed. Monitor for netupitant adverse effects, and for QT effects as palonosetron and posaconazole can both affect QT.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Netupitant-palonosetron
- Apomorphine + Netupitant-palonosetron Contraindicated
- Flibanserin + Netupitant-palonosetron Contraindicated
- Apalutamide + Netupitant-palonosetron Major
- Avapritinib + Netupitant-palonosetron Major
- Carbamazepine + Netupitant-palonosetron Major
- Cobimetinib + Netupitant-palonosetron Major
Other interactions of Posaconazole
- Artemether + Posaconazole Contraindicated
- Avanafil + Posaconazole Contraindicated
- Cobimetinib + Posaconazole Contraindicated
- Conivaptan + Posaconazole Contraindicated
- Dihydroergotamine intranasal + Posaconazole Contraindicated
- Dihydroergotamine + Posaconazole Contraindicated
Frequently asked questions
Can I take Netupitant-palonosetron with Posaconazole?
MediHelp rates the interaction as moderate. Netupitant-palonosetron and Posaconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Posaconazole is a strong CYP3A4 inhibitor and can raise netupitant concentrations. The labeling for netupitant does not require dose adjustment with strong inhibitors, but higher exposure may increase adverse effects such as headache, constipation and fatigue.
How serious is the interaction between Netupitant-palonosetron and Posaconazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No empirical dose adjustment is needed. Monitor for netupitant adverse effects, and for QT effects as palonosetron and posaconazole can both affect QT.
What other medicines interact with Netupitant-palonosetron?
MediHelp also lists interactions of Netupitant-palonosetron with, for example, Apomorphine, Flibanserin, Apalutamide. The full list is on the Netupitant-palonosetron page.
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