Drug interactions
Nevirapine + Nicardipine
Severity: Moderate
Nevirapine and Nicardipine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nevirapine induces CYP3A4 and can lower nicardipine concentrations, which may reduce blood pressure or angina control.
What this interaction means in plain words
Nevirapine and Nicardipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Nevirapine belongs to Anti Virals; Nicardipine belongs to Cardiovascular.
Why it happens
Induction of CYP3A4-mediated nicardipine metabolism by nevirapine.
What to do
Monitor blood pressure and heart rate and titrate nicardipine upward as needed; reassess if nevirapine is stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nevirapine
- Elbasvir / grazoprevir + Nevirapine Contraindicated
- Nevirapine + Ranolazine Contraindicated
- Nevirapine + St john's wort Contraindicated
- Abemaciclib + Nevirapine Major
- Acalabrutinib + Nevirapine Major
- Amobarbital + Nevirapine Major
Other interactions of Nicardipine
Frequently asked questions
Can I take Nevirapine with Nicardipine?
MediHelp rates the interaction as moderate. Nevirapine and Nicardipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nevirapine induces CYP3A4 and can lower nicardipine concentrations, which may reduce blood pressure or angina control.
How serious is the interaction between Nevirapine and Nicardipine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and heart rate and titrate nicardipine upward as needed; reassess if nevirapine is stopped.
What other medicines interact with Nevirapine?
MediHelp also lists interactions of Nevirapine with, for example, Elbasvir / grazoprevir, Ranolazine, St john's wort. The full list is on the Nevirapine page.
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