Drug interactions
Nevirapine + Nimodipine
Severity: Moderate
Nevirapine and Nimodipine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nevirapine may lower nimodipine concentrations because nimodipine is extensively metabolized by CYP3A4. Reduced exposure could diminish its benefit in subarachnoid hemorrhage or blood pressure effects.
What this interaction means in plain words
Nevirapine and Nimodipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Nevirapine belongs to Anti Virals; Nimodipine belongs to Cardiovascular.
Why it happens
CYP3A4 induction by nevirapine increases first-pass and systemic clearance of nimodipine.
What to do
Monitor blood pressure and clinical response to nimodipine; consider an alternative to nevirapine if efficacy appears reduced.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nevirapine
- Elbasvir / grazoprevir + Nevirapine Contraindicated
- Nevirapine + Ranolazine Contraindicated
- Nevirapine + St john's wort Contraindicated
- Abemaciclib + Nevirapine Major
- Acalabrutinib + Nevirapine Major
- Amobarbital + Nevirapine Major
Other interactions of Nimodipine
- Apalutamide + Nimodipine Major
- Carbamazepine + Nimodipine Major
- Ceritinib + Nimodipine Major
- Clarithromycin + Nimodipine Major
- Cobicistat + Nimodipine Major
- Darunavir + Nimodipine Major
Frequently asked questions
Can I take Nevirapine with Nimodipine?
MediHelp rates the interaction as moderate. Nevirapine and Nimodipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nevirapine may lower nimodipine concentrations because nimodipine is extensively metabolized by CYP3A4. Reduced exposure could diminish its benefit in subarachnoid hemorrhage or blood pressure effects.
How serious is the interaction between Nevirapine and Nimodipine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and clinical response to nimodipine; consider an alternative to nevirapine if efficacy appears reduced.
What other medicines interact with Nevirapine?
MediHelp also lists interactions of Nevirapine with, for example, Elbasvir / grazoprevir, Ranolazine, St john's wort. The full list is on the Nevirapine page.
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