Drug interactions
Nevirapine + Paclitaxel
Severity: Moderate
Nevirapine and Paclitaxel: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Paclitaxel is cleared by CYP2C8 and CYP3A4, and nevirapine may induce CYP3A4, potentially lowering paclitaxel exposure. This could reduce antitumor efficacy, though the effect is probably modest.
What this interaction means in plain words
Nevirapine and Paclitaxel can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Nevirapine belongs to Anti Virals; Paclitaxel belongs to Oncology.
Why it happens
Nevirapine induction of CYP3A4 increases paclitaxel metabolism.
What to do
Monitor tumor response and paclitaxel toxicity, and coordinate with oncology and HIV teams; prefer a non-inducing antiretroviral regimen if possible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nevirapine
- Elbasvir / grazoprevir + Nevirapine Contraindicated
- Nevirapine + Ranolazine Contraindicated
- Nevirapine + St john's wort Contraindicated
- Abemaciclib + Nevirapine Major
- Acalabrutinib + Nevirapine Major
- Amobarbital + Nevirapine Major
Other interactions of Paclitaxel
Frequently asked questions
Can I take Nevirapine with Paclitaxel?
MediHelp rates the interaction as moderate. Nevirapine and Paclitaxel can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Paclitaxel is cleared by CYP2C8 and CYP3A4, and nevirapine may induce CYP3A4, potentially lowering paclitaxel exposure. This could reduce antitumor efficacy, though the effect is probably modest.
How serious is the interaction between Nevirapine and Paclitaxel?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor tumor response and paclitaxel toxicity, and coordinate with oncology and HIV teams; prefer a non-inducing antiretroviral regimen if possible.
What other medicines interact with Nevirapine?
MediHelp also lists interactions of Nevirapine with, for example, Elbasvir / grazoprevir, Ranolazine, St john's wort. The full list is on the Nevirapine page.
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