Drug interactions
Nevirapine + Pexidartinib
Severity: Major
Nevirapine and Pexidartinib: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can cause serious liver injury, so combining them may raise the risk of hepatotoxicity. Pexidartinib carries a boxed warning for hepatotoxicity, and nevirapine can cause severe hepatotoxicity.
What this interaction means in plain words
Nevirapine and Pexidartinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Nevirapine belongs to Anti Virals; Pexidartinib belongs to Oncology.
Why it happens
Additive hepatotoxicity from two hepatotoxic drugs.
What to do
Avoid coadministration where possible and choose an alternative antiretroviral. If used, check liver tests frequently and stop pexidartinib for liver injury.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Nevirapine
- Elbasvir / grazoprevir + Nevirapine Contraindicated
- Nevirapine + Ranolazine Contraindicated
- Nevirapine + St john's wort Contraindicated
- Abemaciclib + Nevirapine Major
- Acalabrutinib + Nevirapine Major
- Amobarbital + Nevirapine Major
Other interactions of Pexidartinib
Frequently asked questions
Can I take Nevirapine with Pexidartinib?
MediHelp rates the interaction as major. Nevirapine and Pexidartinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both drugs can cause serious liver injury, so combining them may raise the risk of hepatotoxicity. Pexidartinib carries a boxed warning for hepatotoxicity, and nevirapine can cause severe hepatotoxicity.
How serious is the interaction between Nevirapine and Pexidartinib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid coadministration where possible and choose an alternative antiretroviral. If used, check liver tests frequently and stop pexidartinib for liver injury.
What other medicines interact with Nevirapine?
MediHelp also lists interactions of Nevirapine with, for example, Elbasvir / grazoprevir, Ranolazine, St john's wort. The full list is on the Nevirapine page.
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