Drug interactions
Nevirapine + Propafenone
Severity: Moderate
Nevirapine and Propafenone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nevirapine may lower propafenone concentrations by inducing its CYP3A4-mediated metabolism, potentially reducing antiarrhythmic efficacy. Propafenone has a narrow therapeutic margin, so changes in exposure matter.
What this interaction means in plain words
Nevirapine and Propafenone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Nevirapine belongs to Anti Virals; Propafenone belongs to Cardiovascular.
Why it happens
CYP3A4 induction by nevirapine increases propafenone clearance.
What to do
Monitor ECG and arrhythmia control, adjusting propafenone dose to effect when nevirapine is started or stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nevirapine
- Elbasvir / grazoprevir + Nevirapine Contraindicated
- Nevirapine + Ranolazine Contraindicated
- Nevirapine + St john's wort Contraindicated
- Abemaciclib + Nevirapine Major
- Acalabrutinib + Nevirapine Major
- Amobarbital + Nevirapine Major
Other interactions of Propafenone
- Dofetilide + Propafenone Contraindicated
- Dronedarone + Propafenone Contraindicated
- Nilotinib + Propafenone Contraindicated
- Nirmatrelvir / ritonavir + Propafenone Contraindicated
- Nirmatrelvir + Propafenone Contraindicated
- Pimozide + Propafenone Contraindicated
Frequently asked questions
Can I take Nevirapine with Propafenone?
MediHelp rates the interaction as moderate. Nevirapine and Propafenone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nevirapine may lower propafenone concentrations by inducing its CYP3A4-mediated metabolism, potentially reducing antiarrhythmic efficacy. Propafenone has a narrow therapeutic margin, so changes in exposure matter.
How serious is the interaction between Nevirapine and Propafenone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG and arrhythmia control, adjusting propafenone dose to effect when nevirapine is started or stopped.
What other medicines interact with Nevirapine?
MediHelp also lists interactions of Nevirapine with, for example, Elbasvir / grazoprevir, Ranolazine, St john's wort. The full list is on the Nevirapine page.
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