Drug interactions
Nevirapine + Quetiapine
Severity: Moderate
Nevirapine and Quetiapine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nevirapine may lower quetiapine concentrations, potentially reducing psychiatric symptom control. Effect is predicted from CYP3A4 induction.
What this interaction means in plain words
Nevirapine and Quetiapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Nevirapine belongs to Anti Virals; Quetiapine belongs to Central Nervous System.
Why it happens
Nevirapine induces CYP3A4, the main quetiapine metabolic pathway.
What to do
Monitor psychiatric response and titrate quetiapine upward if needed; reduce the dose if nevirapine is withdrawn.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nevirapine
- Elbasvir / grazoprevir + Nevirapine Contraindicated
- Nevirapine + Ranolazine Contraindicated
- Nevirapine + St john's wort Contraindicated
- Abemaciclib + Nevirapine Major
- Acalabrutinib + Nevirapine Major
- Amobarbital + Nevirapine Major
Other interactions of Quetiapine
- Adagrasib + Quetiapine Major
- Amiodarone + Quetiapine Major
- Amisulpride + Quetiapine Major
- Amoxapine + Quetiapine Major
- Anagrelide + Quetiapine Major
- Apalutamide + Quetiapine Major
Frequently asked questions
Can I take Nevirapine with Quetiapine?
MediHelp rates the interaction as moderate. Nevirapine and Quetiapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nevirapine may lower quetiapine concentrations, potentially reducing psychiatric symptom control. Effect is predicted from CYP3A4 induction.
How serious is the interaction between Nevirapine and Quetiapine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor psychiatric response and titrate quetiapine upward if needed; reduce the dose if nevirapine is withdrawn.
What other medicines interact with Nevirapine?
MediHelp also lists interactions of Nevirapine with, for example, Elbasvir / grazoprevir, Ranolazine, St john's wort. The full list is on the Nevirapine page.
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